Correlation analysis of Herring group C Legg-Calve-Perthes patients and coagulation factors

Abstract

Objective To explore the relationship between the changes of coagulation parameters and Legg-Calve-Perthes disease (hereinafter referred to as Perthes disease) in children with Herring C Perthes disease. Methods Clinical data were retrospectively reviewed for 65 hospitalized patients with Herring C Perthes disease (research group) from January 2012 to June 2016. They underwent unilateral surgery for the first time. The relevant parameters included progression time between initial onset of pain, claudication and other related symptoms after a definite diagnosis of Herring C Perthes disease and the related coagulation parameters. The data were analyzed with regards to in-group correlation. At the same time, 30 children with elective surgery without obvious influence on thrombotic tendency such as olydactyly, clubfoot and so on were included as control group in the same age range. The relevant coagulation parameters were recorded and compared. Results In research group, there was no correlation between prothrombin time (PT), international normalized ratio of prothrombin time (PT.INR), activated partial thromboplastin time (APTT), fibrinogen (Fib), thrombin time (TT), d-dimer (D-Dim) or time of disease progression (|r|>0.7). The coagulation parameters in research group were PT (11.45±0.77) s, PT.INR 0.97±0.06, APTT(28.25±3.36)s, Fib(2.24±0.48)g/L, TT(18.09±1.35)s and D-Dim(0.34±0.72)mg/L. And control group were PT(11.43±0.77)s, PT.INR 1.00±0.08, APTT(30.20±5.06)s, Fib(2.14±0.50)g/L, TT(18.32±1.21)s and D-Dim(0.21±0.16)mg/L. There were no inter-group statistical differences (all P>0.05). Conclusions There is no correlation between disease progression and the coagulation parameters of Perthes disease. Moreover, no significant inter-group difference exists in coagulation parameters. Therefore the result of this research fails to support the assumption that coagulation abnormality is one of the pathogenetic factors for Legg-Calve-Perthes disease. Key words: Blood Coagulation Factors; Legg-Calve-Perthes disease; relevance