Abstract
Objective: In order to discuss the correlation between thyroid function stratification and autoantibody titer in HT patients under different iodine nutritional status. Methods: The serum TH, antibody and urinary iodine levels were measured by the electrochemical immune-luminescent apparatus and iodine-catalyzed arsenic-cerium method in 100 HT patients (HT-A, HT-B, HT-C) with different thyroid functions and 60 healthy subjects. Results: The urinary iodine level of HT patients from HT-A increased in turn along with the progression of the disease, while the levels of FT3, FT4, TT3, TT4 decreased gradually and the levels of TSH and thyroid autoantibodies increased gradually. The urinary iodine level of HT-C group was negatively correlated with the serum FT3, FT4, TT3 and TT4 (P<0.05), while the urinary iodine level of HT-B group was negatively correlated with the serum FT3 and TT4 (P<0.05), and positively correlated with TSH (P<0.05). Along with the progression of HT disease, the levels of serum TPOAb and TGAb increased successively, and there were significant differences among each group (P<0.01). The serum TSH level of high TPOAb group and high TgAb group were respectively higher than those of low TPOAb group, low TgAb group and the control group, the levels of FT3 and FT4 were respectively lower than the low TPOAb group and low TGAb group, but there were no statistically significant on the differences between the FT3 of low TgAb and the levels of T3 and T4 of the control group, high TPOAb group, high TGAb group, low TPOAb group and low TGAb group. Conclusions: Under different iodine nutritional status, if the TH and autoantibody levels of HT patients with different thyroid functions changed correspondingly, it could indicate that the iodine nutritional status is involved in the occurrence and development process of HT of different thyroid functions and antibody levels, and plays an important role in it.
Highlights
Hashimoto Thyroiditis (HT) is a kind of chronic inflammatory Autoimmune Thyroiditis (AIT) that takes its auto-thyroid tissue as the antigen, it is named Chronic Lymphocytic Thyroiditis (CLT), which is a common form of AIT and it is one of the most common types of the Autoimmune Thyroid Disease (AITD)
The levels of thyroid hormone and autoantibodies in 100 HT patients with different iodine nutritional status were compared according to the Median urinary iodine (MUI) level, Results the MUI of iodine deficiency, iodine adequate, iodine excess and iodine over-dose groups were 89.16μg/L, 178.09μg/L, 212.69μg/L and 302.51μg/L respectively
Na Buqi et al [23] investigated the relationship of iodine nutritional status and different levels of urinary iodine with thyroid diseases by taking 2,650 physical examination population in Inner Mongolia Autonomous Region as research objects, and the results showed that the levels of urinary iodine were positively correlated with FT4 and FT3, FT4 was negatively correlated with TSH and TgAb, positively correlated with FT3, and positively correlated with thyroid peroxidase antibody (TPOAb) and TgAb
Summary
Hashimoto Thyroiditis (HT) is a kind of chronic inflammatory Autoimmune Thyroiditis (AIT) that takes its auto-thyroid tissue as the antigen, it is named Chronic Lymphocytic Thyroiditis (CLT), which is a common form of AIT and it is one of the most common types of the Autoimmune Thyroid Disease (AITD). The correlation between Hashimoto's thyroiditis and other thyroid diseases and thyroid autoantibody levels has been widely studied [3,4,5,6]. A large number of epidemiological and clinical studies have been carried out on the relationship between urinary iodine (UI) and thyroid diseases, but the research results are not the same. Taking HT as the research object, there are few studies on the relationship between iodine nutrition level and thyroid function, especially the research on iodine nutrition status in the pathogenesis of HT with different thyroid function and antibody titer. The purpose of this study was to investigate the changes and clinical significance of iodine nutritional status in different thyroid function and antibody levels of HT, and to provide scientific basis for the precise treatment, prevention and pathogenesis of HT
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