Abstract
Objective: To investigate the correlation between thyroid function stratification and autoantibody titers in patients with Graves’ disease (GD) under different iodine nutrition conditions. Methods: The levels of serum thyroid hormones, autoantibodies and urinary iodine in 100 patients with different thyroid function GD [GD-A, GD-B] and 60 healthy subjects are detected by electrochemical immunoluminescence and iodine-catalyzed arsenic-cerium method. Results: The proportion of GD patients with the sum of iodine overdosage and iodine overdosage group is consistent with iodine adequate group, which is significantly higher than iodine deficiency group, and the (Median Urine Iodine, MUI) of GD-A group is significantly higher than GD-B group. Urinary iodine levels in GD group and GD-A group are positively correlated with serum FT3 and FT4 (P<0.05), and negatively correlated with (thyroid stimulating hormone, TSH) (P<0.05). The levels of serum (thyroid peroxidase antibody, TPOAb) and (thyroid globulin antibody, TGAb) in each GD group are significantly higher than those in the control group. Serum TSH levels in the high TPOAb group and high TgAb group are lower than those in the low TPOAb group, low TgAb group and control group, respectively. The levels of FT3 and FT4 are higher than those of the low TPOAb group and the low TgAb group, however, there is no significant difference between the FT3 of low TgAb and T3 and T4 levels that belong to the control group, high TPOAb group, high TgAb group, low TPOAb group, and low TgAb group. In conclusion: GD patients with different thyroid functions have corresponding changes in their thyroid hormone and autoantibody levels under different iodine nutrition conditions, which indicates that iodine nutrition status involve in and play an important role in the development of GD with different thyroid functions and different antibody levels.
Highlights
Graves' Disease (GD) that known as toxic diffuse goiter, is a common clinical endocrine disease and the most common autoimmune thyroid disease (Autoimmune thyroid disease, AITD), which is the highest incidence of all types of hyperthyroidism
Comparison of Clinical Characteristics of GD Patients with Different Thyroid Functions thyroid function are compared with the control group, and the difference is not statistically significant (χ2=2.681, P=0.536 vs χ2=0.873, P=0.627)
The composition ratio of GD patients with different urinary iodine concentrations, the sum of iodine overdose and iodine overdose group is consistent with the proportion of iodine adequate group, which is significantly higher than iodine deficiency group
Summary
Graves' Disease (GD) that known as toxic diffuse goiter, is a common clinical endocrine disease and the most common autoimmune thyroid disease (Autoimmune thyroid disease, AITD), which is the highest incidence of all types of hyperthyroidism. About 80% to 86% of hyperthyroidism is caused by GD. The clinical symptoms or signs of GD mainly include diffuse symmetrical goiter and hyperfunction, exophthalmos, and hypermetabolic state. It can be onset at any age, but it is more common in women. There are many factors in the pathogenesis of GD, such as environmental, genetic, and autoimmune dysfunction, all that can lead to specific autoimmune reactions in the thyroid gland, diffuse goiter, and hyperthyroidism [3].
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