Correlation analysis between sleep quality and mild cognitive impairment in elderly patients with type 2 diabetes mellitus

Abstract

Objective To investigate the relationship between sleep quality and mild cognitive impairment(MCI) in elderly patients with type 2 diabetes mellitus(T2DM).Methods We collected 97 elderly patients with type 2 diabetes mellitus and divided them into two groups: MCI group(DM-MIC) and normal cognition group(DM-NC group).All subjects were evaluated with cognition scores of Mini-mental state examination(MMSE),Montreal Cognitive Assessment(MOCA),Self-Rating Anxiety Scale(SAS),Center for Epidemiogical Studies Depression Scale(CES-D),Activity of daily living(ADL),Global Deterioration Scale(GDS),and Pittsburgh sleep quality index(PSQI).Independent t-test and Spearman's rank correlation analysis were performed.Results The hypnotic use in DM-MCI group was significantly more than that in DM-NC group(P=0.046),and it had a negative correlation with the score of delayed recall,but not statistically significant(r=-0.277,P=0.062).Significantly negative correlations were also found between the score of PSQI and MOCA(r=-0.362),PSQI and attention(r=-0.319),PSQI and delayed recall(r=0.409),daytime dysfunction and MOCA(r=-0.393),daytime dysfunction and abstraction(r=-0.337),night sleep disorders and language(r=-0.439),sleep efficiency and delayed recall(r=-0.325),and subjective sleep quality and delayed recall(r=-0.336) in DM-MCI group(P0.05).Conclusion Sleep quality is correlated with some symptoms of mild cognitive impairment in elderly patients with T2DM.