Association of serum cystatin C and risk of mild cognitive impairment in elderly patients with type 2 diabetes mellitus

Abstract

Objective To investigate the association of serum Cystatin C level and mild cognitive impairment(MCI)in elderly people with type 2diabetes mellitus(T2DM)and to analyze the risk factors for MCI.Methods A total of 156elderly people with type 2diabetes mellitus were divided into two groups:MCI and normal cognition(NC)group.All subjects were evaluated with cognition scores of Mini-mental state examination(MMSE),Montreal Cognitive Assessment(MoCA),SelfRating Anxiety Scale(SAS),Center for Epidemiogical Studies Depression Scale(CES-D),Screening Scale for Parkinson disease(SSPD),Activity of Daily Living(ADL),and Global Deterioration Scale(GDS).CystatinC,HbA1c,triglyceride(TG),total cholesterol(TC),and blood pressure were examined.Independent t-test,correlations and logistic regression analysis were performed.Results The elderly diabetic patients complicated with MCI showed a higher level of serum Cystatin C than those in NC group(P=0.018).Cystatin C was negatively correlated with the score of MMSE,and score,visuospatial/ executive,naming,attention,language and delayed recall of MOCA(P0.001).Logistic regression analysis showed that diabetes duration,hypertension,HbA1cand Cystatin C were the variables of the equation.Conclusion Multiple risk factor including the higher level of serum Cystatin C may induce MCI in elderly T2DM people,but larger sample study is needed for further verification.