Abstract

Aim: The aim of this study was to investigate the correlation between biochemical, functional and structural markers of endothelium damage. Material and methods: 68 patients with essential hypertension were included in a prospective study. We studied biochemical markers respectively functional and structural evaluation. Results: A higher mean values of sICAM-1 (380 respectively 334) and hs-CRP (4, 31 respectively 3, 32) was observed in the first two groups with endothelial dysfunction as compared with the control group (227 respectively 1, 91). The mean values of sP-selectin was higher for the first group (134) compared also with the second and the third groups (88 respectively 68, p < 0,001) with normal values. Conclusions: High ICAM-1, P-selectin and hs-CRP plasma levels was observed and a significant correlation with structural changes and with functional changes in endothelium dependent FMD and could be used as a biochemical marker of endothelial dysfunction.

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