Abstract
Positive pressure ventilation (PPV) is a fundamental life support measure, but it decreases cardiac output (CO). Diaphragmatic contractions produce negative intrathoracic and positive abdominal pressures, promoting splanchnic venous return. We hypothesized that: 1) diaphragm pacing alone could produce adequate ventilation without decreasing CO; 2) diaphragm pacing on top of PPV could improve CO. Of 11 anesthetized and mechanically ventilated ewes (39.6±5.9kg), 3 were discarded from analysis because of hemodynamic instability during the experiment, and 8 retained for analysis. Phrenic stimulation electrodes were inserted in the diaphragm (implanted phrenic nerve stimulation, iPS). CO was measured by the thermodilution technique (pulmonary artery catheter). CO during end-expiratory apnea served as reference. Median CO was 9.77 [6.25–11.25] lmin−1 during end-expiratory apnea, 8.25 [5.06–9.25] lmin−1 during “PPV” (−15%) (p<0.05), 9.19 [5.60–10.19] lmin−1 during “PPV-iPS” (NS vs apnea) and 9.37 [6.12–10.48] lmin−1 during “iPS” (NS vs. apnea). iPS-driven ventilation was comparable to its PPV counterpart (median 92% [74–97], NS). Diaphragm pacing alone can produce adequate ventilation without reducing CO. Superimposed onto PPV, diaphragm pacing can reduce the PPV-induced decrease in CO.
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