Correction

Abstract

2012. Tuning membrane phase separation using nonlipid amphiphiles. Biophys. J. 102:489–497. The abbreviated lipid name, DUPC, refers to 1,2-dilinoleoyl-sn-glycero-3-phosphocholine (18:2 PC) throughout the article. This was erroneously reported as 1,2-diundecanoyl-sn-glycero-3-phosphocholine (11:0 PC) in the Abstract of the article. On page 492, first column, lipid shells around vitamin E were referred to as “lipid hydration shell”, and should be corrected to “lipid solvation shell”. On page 494, first column, the sentence “Previous studies have shown that cholesterol partitions preferentially with gel phase lipid because of its high affinity for fully saturated lipids” should be corrected to “Previous studies have shown that cholesterol partitions preferentially with ordered lipid because of its high affinity for fully saturated lipids”. Tuning Membrane Phase Separation Using Nonlipid AmphiphilesMuddana et al.Biophysical JournalFebruary 08, 2012In BriefLipid phase separation may be a mechanism by which lipids participate in sorting membrane proteins and facilitate membrane-mediated biochemical signaling in cells. To provide new tools for membrane lipid phase manipulation that avoid direct effects on protein activity and lipid composition, we studied phase separation in binary and ternary lipid mixtures under the influence of three nonlipid amphiphiles, vitamin E (VE), Triton-X (TX)-100, and benzyl alcohol (BA). Mechanisms of additive-induced phase separation were elucidated using coarse-grained molecular dynamics simulations of these additives in a liquid bilayer made from 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and 1,2-diundecanoyl-sn-glycero-phosphocholine (DUPC). Full-Text PDF Open Archive