Abstract
[This corrects the article DOI: 10.18632/oncotarget.8455.].
Highlights
Many therapeutic drugs generally exhibit actions on more than one molecular target, which is a phenomenon known as polypharmacology [1]
Connectivity MAP (CMAP), a chemical genomics database that collects gene-expression profiles from cultured human cells treated with small molecules, can be used to find connections among small molecules that share common action mechanisms [5]
It is commonly accepted that polypharmacology is a basic property of small molecules, which is an important basis for drug repurposing [2]
Summary
Many therapeutic drugs generally exhibit actions on more than one molecular target, which is a phenomenon known as polypharmacology [1]. Our previous study successfully identified novel action mechanisms of the Chinese herbal medicine, berberine, using a gene expression signature-based approach [4] This approach integrates the Connectivity MAP (CMAP) that collects gene-expression profiles from cultured human cells treated with small molecules [5], and the Search Tool for Interactions of Chemicals (STITCH) that explores known www.impactjournals.com/oncotarget and predicted interactions of chemicals and proteins by evidence derived from experiments, databases, and the literatures [6]. More and more biomedical databases and analytical tools have been developed in recent years, which provide easy and open access to masses of accumulated data [3] Integration of these resources will be highly useful in the field of polypharmacology
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