Correction of natural resistance indicators in calves with abomazoenteritis

Abstract

Diseases of the digestive system, especially of ounganimals, are widespread and cause significant material lossesto farms of all types of property. Therefore, it is importantto develop a complex treatment that affects all links ofpathogenesis, accelerates recovery and at the same timedoes not have a toxic effect on the body of young animals.There search was carried out in the farms of the Lviv region on black-and-white calves at the age of 1.5–2 months of age.The animals of the research groups were diagnosed withabomazoenteritis. Clinically healthy animal analogs served ascontrol. It was previously established that in calves patientswith abomazoenteritis, the bactericidal activity of bloodserum (BABS), lysozyme activity of blood serum (LABS)and indicators of the activity of phagocytosis of neutrophilsdecrease. The animals were treated with diet, antibiotic therapy,rehydration and vitamin therapy. In addition, the calves of oneof the research groups received the oral drug Selenium (SelPlex) and the intramuscular drug Germanium (Maxidin 0.4)as antioxidants and immunomodulators. The dat aobtained byus indicate that the use of these drugs in the complex therapyof patients with abomazoenteritis of calves contributed to theacceleration of the clinical recovery of calves (on average by2 days). The positive effect of the Selenium and Germaniumpreparations on the indices of nonspecific resistance was alsoestablished: BABS and LABS on the seventh day of the studywere higher (p<0.001) than in animals to which these drugswere not used and amounted to 41.0±0.51 and 19.5±0.45 %respectively. Similar changes were revealed as indicatorsof phagocytosis. Phagocytic activity of neutrophils (FA)was higher than the third (p<0.05), seventh (p<0.01) andfourteenth (p<0.01) days of the study. The phagocytic index(PI) of the seventh (p<0.001) and the fourteenth (p<0.001)day of research compared with the group of animals whereSelenium and Germanium were not used. The studies carriedout indicate that the use of Sel-Plex and Maxid in 0.4 in thecomplex treatment of calves with abomazoenteritis acceleratedthe recovery of animals, in particular through a positive effecton the indices of nonspecific resistance. Key words: younganimals, digestive disorders,Selenium, Germanium, phagocytosis, bactericidal, lysozymeactivity of blood serum.