Abstract
Unfortunately, in this article (in this issue) the labels indicating the different groups in column “Donors” are missing in the published Fig. 4. The complete correct Fig. 4 is as given here: IFN-γ responses to P. vivax proteins in humans with different Duffy phenotypes. Frozen PBMC from Fy(–) P. vivax exposed individuals, Fy(+) P. vivax exposed individuals, or unexposed controls were assayed for IFN-γ induction by ELISPOT after stimulation with autologous B or M-DC transfected with novel P. vivax proteins. As positive controls, IFN-γ responses in Fy(–) individuals were detected preferentially to known P. vivax sporozoite Ag (CSP or SSP2) but not to blood stage Ag (MSP-1, AMA-1, or DBP), whereas, the responses in Fy(+) humans were detected to both sporozoite and blood stage Ag. IFN-γ responses to eight novel P. vivax proteins were detected in P. vivax exposed individuals, but not in unexposed controls. IFN-γ responses to three of the eight responded P. vivax Ag (PVA9, PVA20 and PVA22) were detected only in Fy(–) but not Fy(+) individuals who were exposed to P. vivax, whereas the responses to other five Ag (PVA3, PVA16, PVA18, PVA19, PVA21) were detected in both Fy(–) and Fy(+)P. vivax exposed individuals. IFN-γ responses to PVA6, PVA13 and PVA17 were detected in 18 of the 19 donors tested including P. vivax exposed and unexposed controls, indicating these three Ag are cross-reactive T cell Ag; a the numbers in the black boxes indicate the number of Ag-specific IFN-γ-producing cells/million PBMCs;b based on proteomics analysis by Florens et al. [16]; spz, sporozoite; mrz, merozoite; tpz, trophozoite; gmt, gametocyte. See original article http://dx.doi.org/10.1002/eji.200425807
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