Abstract
Defining pathways that differentially regulate graft-reactive versus anti-microbial Tcell responses could facilitate more precise manipulation of immune responses in the context of organ and tissue transplantation. Here, Jayachandran etal. (2019) identify a coronin-1-PDE4-cAMP axis that, when perturbed, results in the induction of transplantation tolerance while maintaining anti-microbial immunity.
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