Abstract
Background and Aims: ROR-alpha is a member of ligand-activated nuclear receptor superfamily of transcription factors. Melatonin and cholesterol are two known ligands of ROR-alpha, both of which were shown to be important for atherosclerosis. The aim of this study was to determine differentially expressed miRNAs in coronary artery disease (CAD) patients, and to test the dependence of their expression on ROR-alpha activity in THP-1 macrophage cells.
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