Corneal Biomechanical Properties in Normal, Forme Fruste Keratoconus, and Manifest Keratoconus After Statistical Correction for Potentially Confounding Factors

Abstract

To evaluate the difference in corneal biomechanical properties, after controlling for potentially confounding factors, along the spectrum of keratoconic disease as measured by the keratoconus severity score. The corneal biomechanical properties of 73 keratoconic (KCN) eyes of 54 patients, 42 forme fruste keratoconic (FFKCN) eyes of 32 patients, and 115 healthy eyes of 115 age- and sex-matched patients were reviewed retrospectively. The main outcome measures were corneal hysteresis (CH) and corneal resistance factor (CRF). In the normal group, the mean CH was 11.0 ± 1.4 mm Hg and mean CRF was 11.1 ± 1.6 mm Hg. The FFKCN mean CH was 8.8 ± 1.4 mm Hg and mean CRF was 8.6 ± 1.3 mm Hg. The KCN mean CH was 7.9 ± 1.3 mm Hg and mean CRF was 7.3 ± 1.4 mm Hg. There were statistically significant differences in the mean CH and CRF in the normal group compared with the FFKCN and the KCN groups (P < 0.001) after statistically controlling for differences in central corneal thickness, age, and sex. There is a significant difference in the mean CH and CRF between normal and FFKCN corneas after controlling for differences in age, sex, and central corneal thickness. However, there is a significant overlap in the distribution of CH and CRF values among all groups. The biomechanical parameters CH and CRF cannot be used alone but may be a useful clinical adjunct to other diagnostic tools, such as corneal tomography, in distinguishing normal from subclinical keratoconic corneas.