Abstract
A sensitive electroanalytical method for determination of pentoxyfylline (PENT) in pharmaceutical formulation has been investigated on the basis of the enhanced electrochemical response at copper/zinc/iron composite modified glassy carbon electrode (Cu-Zn-Fe/GCE) in water. The morphological characteristics and charge transfer properties of the developed Cu-Zn-Fe/GCE sensor were studied by scanning electron microscopy (SEM) and electrochemical impedance spectroscopy (EIS) respectively. The influence of optimization parameters such as pH, effect of different solvents and effect of loading of composite mixture of Cu-Zn-Fe at GCE on analytical performance of the developed sensor were investigated. The developed squarewave voltammetric method shows linearity over the concentration 50 (ng mL−1) to 50 (μg mL−1) with a correlation coefficient (r2) of 0.9974. The detection limit (LOD) and quantification limit (LOQ) were found to be 8.05 ng mL−1 and 26.85 ng mL−1 respectively. The sensor exhibits a significant catalytic effect on PENT oxidation with an acceptable reproducibility of 2.03% relative standard deviation (RSD). The fabricated sensor shows great promise for simple, sensitive, quantitative screening and detection of PENT using voltammetric techniques.
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