Copper-mediated synthesis of N-arylated cyclic urea from diaminecarbamate

Abstract

A convenient base-promoted CuI-mediated intermolecular synthesis of N-arylated cyclic ureas from diaminecarbamate and aryl iodides was developed. A series of N-arylated five- and six-membered cyclic ureas were successfully afforded in moderate to good yields. This new protocol features mild reaction conditions, noble metal-free and ligand-free system, and diverse products.