Abstract
The purpose . Тo compare the level copeptin in healthy volunteers and subjects with grade II-III stage and to communicate copeptin with indicators of peripheral and сentral hemodynamics, lipid spectrum. The design and methods. The study included 32 patients with essential hypertension stage II-III and 21 patients in the control group aged 40 to 66 years. The subjects were conducted: physical examination, electrocardiography, echocardiography, biochemical blood analysis, indirect arteriography, determination of glomerular ᔆltration rate. Copeptin level in blood plasma under investigation was determined by ELISA on microplate photometer Zenyth 1100. Was conducted correlation analysis, the comparison of two independent groups by Mann-Whitney test. Statistically signiᔆcant were considered dierences at p<0.05. Results. Established that the level of copeptin plasma, reflecting the level of vasopressin in plasma, in patients with essential hypertension II-III stage was statistically signiᔆcantly higher than in healthy volunteers (p<0.05). Statistically signiᔆcant direct correlation between the level copeptin and triglycerides (r= 0,565; p=0.03), levels of cholesterol of very low density lipoproteins (r= 0,565; p=0.003), atherogenic coeܝcient (r= 0,477; p=0.016), a statistically signiᔆcant inverse correlation between the level copeptin and the level of cholesterol high density lipoprotein (r= -0,432; p=0,031). Statistically signiǁcant inverse correlation between glomerular ǁltration rate and the сentral systolic blood pressure (SBP) (r= -0,415; p=0.039), glomerular ǁltration rate and сentral pulse pressure (r= -0,422; p=0.036). Conclusion. The study established that the level of vasopressin in essential hypertension increases dramatically. Statistically signiǁcant correlation copeptin with the levels of triglycerides, level of cholesterol high density lipoprotein, levels of cholesterol of very low density lipoproteins, atherogenic coeɐcient, statistically signiǁcant correlation of glomerular ǁltration rate with сentral pulse pressure and сentral SPB.
Highlights
The study established that the level of vasopressin in essential hypertension increases dramatically
Rasprostranennost’ faktorov riska serdechno-sosudistyh zabolevanij v rossijskoj populjacii bol’nyh arterial’noj gipertoniej
Summary
The study established that the level of vasopressin in essential hypertension increases dramatically. В настоящее время сформулировано несколько теорий патогенеза гипертонической болезни: нейрогенная теория, мембранная теория, теория нейрогуморального дисбаланса. При гипертонической болезни эндотелиальная дисфункция проявляется в виде снижения вазодилатирующей функции эндотелия резистивных сосудов из-за дефицита оксида азота [3]. Уровень копептина в плазме крови у пациентов с гипертонической болезнью происходит под действием различных факторов [1]. Через V1A-рецепторы (AVPR1A), встроенные в мембраны гладкомышечных клеток сосудов, реализуется вазопрессорный эффект вазопрессина [1, 2]. Через V2-рецепторы (AVPRV2), локализованные в мембранах клеток собирательных трубочек почек, реализуется антидиуретический эффект вазопрессина [2]. В 2007 году предложили оценивать уровень вазопрессина в крови по его производному – копептину. Копептин секретируется в кровь в эквимолярном вазопрессину количестве, но, в отличие от вазопрессина, сохраняется в крови в течение нескольких суток [8, 13].
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