Abstract
Transition metal complexes of Co(II), Ni(II) and Cu(II) metal ions with general stoichiometry [M(L)X]X and [M(L)SO4], where M = Co(II), Ni(II) and Cu(II), L = 3,3’-thiodipropionic acid bis(4-amino-5-ethylimino-2,3-dimethyl-1-phenyl-3-pyrazoline) and X = NO3−, Cl− and OAc−, have been synthesized and structurally characterized by elemental analyses, molar conductance measurements, magnetic susceptibility measurements and spectral techniques like IR, UV and EPR. The nickel(II) complexes were found to have octahedral geometry, whereas cobalt(II) and copper(II) complexes were of tetragonal geometry. The covalency factor (β) and orbital reduction factor (k) suggest the covalent nature of the complexes. The ligand and its complexes have been screened for their antifungal and antibacterial activities against three fungi, i.e. Alternaria brassicae, Aspergillus niger and Fusarium oxysporum and two bacteria, i.e. Xanthomonas compestris and Pseudomonas aeruginosa.
Highlights
The transition metal complexes of 4-aminoantipyrine and its derivatives have been extensively examined due to their wide applications in various fields like biological, analytical and therapeutical [1−4]
A number of research articles have been published on transition metal complexes derived from 4-aminoantipyrine derivatives with aza or aza-oxo donor atoms [8−11]
We were interested in examining the biological activities of NS-donor Schiff’s bases and their transition metal complexes, in this article, we report the antifungal and antibacterial activities of the pentadentate (NNSNN-donor)
Summary
The transition metal complexes of 4-aminoantipyrine and its derivatives have been extensively examined due to their wide applications in various fields like biological, analytical and therapeutical [1−4]. Schiff’s base ligand 3,3’-thiodipropionic acid bis(4-amino-5-ethylimino-2,3-dimethyl-1-phenyl-3pyrazoline) and its complexes with Co(II), Ni(II) and Cu(II) metal ions. The synthesized novel Schiff’s base ligand, 3,3’-thiodipropionic acid bis(4-amino-5-ethylimino2,3-dimethyl-1-phenyl-3-pyrazoline) (Scheme 1) forms stable complexes with Co(II), Ni(II) and The 13C-NMR spectrum (Figure 3) displays the signals corresponding to the different non-equivalent carbon atoms at different values of δ as follows: at ca.
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