Coordinated expression of c-myc gene and a multigenic set may modulate the malignant phenotype in human haemopoietic cell lines.

Abstract

We previously showed that about 2000 non repeated DNA sequences of 3 Kbs each, designated as tumor-activated DNA (Ta- DNA), are transcriptionally activated in human neoplasias [1, 2]. A growing body evidence supports the concept that oncogenic transformation may depend on abnormal activation of cellular oncogenes (see general reviews [3, 4]), resulting in gene amplification, chromosomal rearrangements [5], or point mutations [6] and possibly involving cooperative oncogenes [7].KeywordsRetinoic AcidRaji CellDifferentiation InducerCellular OncogeneNamalwa CellThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.