Abstract
AbstractCooperative NHC/photoredox catalysis has emerged as an important research field in recent years. Herein, the use of tertiary alcohols as alkyl radical precursors to perform three component radical coupling with styrenes and aroyl fluorides for the preparation of α‐arylated alkyl aryl ketones is described. Reaction of an aroyl fluoride with the NHC catalyst provides an acyl azolium ion that can be reduced by the photoredox catalyst to the corresponding ketyl radical anion. Oxidatively generated C‐radicals derived from the alcohol add to the styrene derivative and subsequent cross coupling of the adduct radical with the ketyl radical delivers after NHC fragmentation the targeted ketone.magnified image
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
