Cooperative effects of inherent stochasticity and random long-range connections on synchronization and coherence resonance in diffusively coupled calcium oscillators

Abstract

The cooperative effects of inherent stochasticity and random long-range connections (RLRCs) on synchronization and coherence resonance in networks of calcium oscillators have been investigated. Two different types of collective behaviors, coherence resonance (CR) and synchronization, have been studied numerically in the context of chemical Langevin equations (CLEs). In the CLEs, the reaction steps are all stochastic, including the exchange of calcium ions between adjacent and non-adjacent cells through the gap junctions. The calcium oscillators’ synchronization was characterized by the standard deviation of the cytosolic calcium concentrations. Meanwhile, the temporal coherence of the calcium spike train was characterized by the reciprocal coefficient of variance (RCV). Synchronization induced by RLRCs was observed, namely, the exchange of calcium ions between non-adjacent cells can promote the synchronization of the cells. Moreover, it was found that the RCV shows a clear peak when both inherent stochasticity and RLRCs are optimal, indicating the existence of CR. Since inherent stochasticity and RLRCs are two essential ingredients of cellular processes, synchronization and CR are also important for cells’ functions. The results reported in this paper are expected to be useful for understanding the dynamics of intercellular calcium signaling processes in vivo.