COHERENCE RESONANCE BY EITHER INTERNAL NOISE OR EXTERNAL NON-GAUSSIAN NOISE IN INTRACELLULAR CALCIUM OSCILLATIONS

Abstract

In this paper, we study the effects of both internal Gaussian noise and external non-Gaussian noise (NGN) on the temporal coherence of intracellular calcium oscillations. It is found that for a small cell volume internal noise can induce coherence resonance (CR) when external noise strength is small, and for a large cell volume external NGN can induce CR when noise strength, correlation time or the deviation from Gaussian distribution is varied. These results show that the calcium oscillation coherence can be optimized by either internal noise or external noise, depending on the cell volume. Furthermore, external NGN can optimize the oscillations in different ways by varying its noise strength, correlation time, or the deviation from Gaussian distribution. These findings imply that CR may appear frequently in the calcium oscillations when internal noise and external NGN coexist. This may help to entirely understand the constructive roles of internal noise and external NGN in the calcium oscillations.