Convenient synthetic approach to poly(N‐Methyl L‐alanine) through polycondensation of activated urethane derivative of N‐methyl L‐alanine

Abstract

This study describes a convenient and phosgene-free synthesis of poly(N-methyl L-alanine) with solubility in water using polycondensation of activated urethane derivative of N-methyl L-alanine was described. The polycondensation of activated urethane derivative was heated at 60 °C with n-butylamine as an initiator to give the corresponding poly(N-methyl L-alanine), accompanying the elimination of phenol and CO2. The investigation of SEC and MALDI TOF mass spectrometry characterized the control of molecular weight and terminal structure. Additional Supporting Information may be found in the online version of this article. Supporting Information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.