Abstract
A NESTHETIZING PATIENTS with neurologic diseases is always a challenge for anesthesiologists. Multiple sclerosis (MS) is no exception. In this disease, demyelination of both grey and white matter occurs. Plaques form or sclerosis takes place in these areas of demyelination leading to contiguousness of nodes of Ranvier and, if the area is extensive enough, failure of electrical conduction. Peripheral nerves are not affected, and the lesions are upper-motor and not lower-motor neuron. Spasticity and incoordination of laryngeal and pharyngeal muscles may occur, leading to inadequate or ineffective airway protection during exacerbations. Autonomic dysfunction can occur; contractures and spasms of muscles in the extremities, visual involvement, etc.
Published Version
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