Abstract
SUMMARY A controlled test was done in 30 naturally infected ponies to evaluate the antiparasitic activity of the dienbendazole analog VET 220-S given alone or with trichlorfon (tcf) by nasogastric intubation. Six ponies were nontreated; 6 were given VET 220-S (5.0 mg/kg); 6 were given tcf (40 mg/kg); 6 were given VET 220-S (2.5 mg/kg) and tcf (40 mg/kg); and 6 were given VET 220-S (5.0 mg/kg) and tcf (40 mg/kg). All ponies were euthanatized and necropsied 7 or 8 days after treatment. Draschia megastoma, Oxyuris equi, Strongylus vulgaris, S edentatus, and small strongyles were removed efficaciously by all doses of VET 220-S. Habronema muscae and microfilariae of Onchocerca cervicalis were not removed by VET 220-S or tcf. Gasterophilus intestinalis was 97.9% removed by tcf. Pregnant mares in all groups were not adversely affected by treatment, except for 1 mare that had diarrhea after tcf treatment. Parasite eggs per gram and larval culture data agreed with necropsy data.
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