Abstract
Summary A controlled trial was performed to titrate the antiparasitic dosage of moxidectin in 40 mixed-breed ponies naturally infected with Strongylus vulgaris , and/or S. edentatus , and small strongyle species, as determined by parasitic egg and larval counts of feces. Moxidectin was given orally at 0, 0.3, 0.4 and 0.5 mg/kg of body weight in a gel vehicle. All ponies were euthanized and necropsied at 14 days after treatment. Strongylus vulgaris, S. edentatus , small strongyle species, Onchocerca cervicaIis microfilariae, Habronema muscae, Oxyuris equi larvae, and Gasterophilus species were eliminated in response to all doses of moxidectin. Anoplocephala spp. were not affected by any dose. There were not sufficient numbers of Trichostrongylus axei, Draschia megastoma, Parascaris equorum , or mature Oxyuris equi in the ponies to evaluate the effectiveness of moxidectin against them. All dosage levels of moxidectin produced a profound reduction in the extent of intestinal inflammation. Moxidectin was highly effective in reducing the numbers of coiled strongyle larvae and larvae in nodules in the cecal and colonic mucosa. There appeared to be an inverse relationship between age of pony and the extent of reduction in intestinal inflammation in response to moxidectin treatment. No adverse effects were attributable to moxidectin treatment.
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