Controlled release of antibiotic cobex by biosynthesize copper nanoparticles using Osmium sanctum and its antibacterial activity

Abstract

The work was intended to synthesize copper nanoparticles (CuNPs) via eco-friendly green approach using Osmium sanctum leaf extract. The development of CuNPs was assured using techniques like transmission electron microscopy (TEM) and Fourier transform infra red spectroscopy (FTIR). Synthesized CuNPs were used as a device for sustained release of cobex drug. The release behavior of the drug was carried out in precise physiological conditions. The drug release behaviour showed higher drug release at alkaline pH followed by neutral and acidic pH. The maximum drug release occurred after 34 h with maximum drug release 972.4 (DL = 2.89 m2/h), 895.5 ppm, DL = 2.12 m2/h) and 626.15 ppm, DL = 1.98 m2/h at pH 9.2, 7 and 2, respectively. Drug release behaviour followed non-fickian type of diffusion mechanism. Antibacterial activity of the synthesized CuNPs was also studied and it was found that they are very effective against the different strains of bacteria like E.coli, Pseudomonas aeruginosa, Klebsiella spp. and Staphylococcus aureus.