Synthesis of 4-Acryloylmorpholine-based Hydrogels and Investigation of their Drug Release Behaviors

Hülya Efe,Nilhan Kayaman-Apohan,Memet Vezir Kahraman,Merve Bicen

doi:10.5935/0103-5053.20130107

Abstract

In this study, hydrogels based on an amphiphilic, water soluble, bisubstituted and biocompatible acrylamide derivative, namely 4-acryloylmorpholine (4-AcM), were prepared. 4-AcM based hydrogels with different compositions were synthesized by photopolymerization from the mixtures of poly(ethylene glycol) diacrylate (PEG-DA) and poly(2-hydroxy ethyl methacrylate) (HEMA), and characterized by Fourier transform infrared spectroscopy (FTIR). Gel percentage and equilibrium swelling ratios were determined. Images obtained by scanning electron microscopy (SEM) confirmed porous structure of the hydrogels. Ciprofloxacin.HCl was chosen as a model drug in order to understand the drug loading and release behaviors of the hydrogels. As 4-AcM content increased, higher drug release was observed. On the other hand, the increase in crosslinking density due to PEG-DA content resulted in the swelling decrease of the hydrogel and reduced the diffusion of the drug.

Highlights

Hydrogels are of great interest in the biomedical area because of their hydrophilic and biocompatible nature as well as mechanical strength.[1]
The equilibrium swelling ratios increased with the increase of the 4-Acryloyl morpholine (4-AcM) content and decreased with the increase of poly(ethylene glycol) diacrylate (PEG-DA)
Scheme 1a shows the synthesis of the 4-AcM‐based hydrogels

Summary

Introduction

Hydrogels are of great interest in the biomedical area because of their hydrophilic and biocompatible nature as well as mechanical strength.[1]. There is no study which involves ciprofloxacin.HCl drug release of hydrogels based on 4-AcM prepared by UV curing technique. The equilibrium swelling ratio of hydrogels is affected by the PEG-DA content.

Results

Conclusion