Abstract
Microparticles with entrapped ovalbumin (OVA) were prepared using two different poly(lactide-co-glycolide) polymers (Resomers RG 506 and 755) with different rates of degradation and were orally administered to two groups of mice. Both groups showed enhanced serum IgG and salivary IgA antibody responses in comparison to a group of mice immunized with soluble OVA. but the level of responses induced depended on the polymer. The more rapidly degrading polymer (RG 506) was most effective for the induction of high levels of salivary IgA antibodies, while the more slowly degrading polymer (RG 755) was most effective for the induction of serum IgG antibodies.
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