Abstract
Average size of hematite and magnetite micro and nanopowders and polydispersity index, zeta potential and distribution of particles were studied. Analysis showed that average size of the obtained particles for magnetite is 740.9 nm, for hematite particles 30 - 35 nm. Alternate current feed source was created for hyperthermia. Proceeding from the requirements of the objectives, the U type MnZn material magneto conductors were selected, in which 10.0 and 8.0 mm width gaps were cut and glass test tubes with magnetite or hematite suspensions were placed in them. Series of experiments at various field intensity and frequencies showed that for efficient magnetic hyperthermia therapy more powerful device was needed with frequency of up to 10 Mega Hertz to achieve the temperature 43°C - 45°C necessary for full activation of Neel and Brown mechanisms in particles. At the next stage, on the basis of experimental material the anticancer mono-therapeutic effect of hyperthermia and its adjuvant action in poly chemotherapeutic treatment was presented by the use of a device created by us “Lezi”. As a result of the experiment it was shown that in all animals (outbred albino mice, 3 months old) inhibition of cancer growth was fixed and intratumoral necrosis was developed, while after 7 and 10 sessions tumors were ulcerated, which refers to positive effect of the experiment (Conclusion of Pathologicanatomical Laboratory “PATGEO”, Tbilisi, Georgia ).
Highlights
It is known that malignant cancers consist of cancer cells, which differ from normal ones by uncontrolled and unlimited propagation and growth of cells
A series of experiments was carried out that showed that increase of temperature by 6 ̊C - 7 ̊C in 5 min period in tubes was conditioned by thermal effect of magnetic conductor in gaps. As it was shown by the experiments, more powerful device of 5 - 10 mega Herz is needed for efficient treatment by magnetic hyperthermia to enable thorough activation of Neel and Brawn mechanisms at the impact of alternate magnetic field on micro- and nanopowders obtained by us
In the I group of mice we studied anticancer therapeutic effect of hyperthermia
Summary
It is known that malignant cancers consist of cancer cells, which differ from normal ones by uncontrolled and unlimited propagation and growth of cells. In this glass Yttrium-89 (89Y) is nonradioactive isotope, which is found in nature at 100%, but neutron irradiation results in activation of 89Y, which results in creation of β-irradiating 90Y, half-life of which equals to 64.1 hr When these 20 - 30 mcm diameter radioactive glass microspheres are injected into organism (e.g. liver cancer) they fall into narrow blood vessels of cancer and block delivery of nutrients. Alongside with it, it gives highionized β-rays acting at short distances. Radioactivity of 90Y at neutron irradiation [6] decreases to insignificant level in 21 days; microspheres lose activity after treatment of cancer They are used already clinically for liver cancer therapy in Canada, USA and China. Development of new methods of treatment of melignancies is the most urgent task of oncology Inculcation of drugs and methods of treatment possessing positive effects which are proved by experimental and clinical studies into clinical practice are forward steps in the sphere of treatment of oncologic patients
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