Abstract
In this study, we investigated in cytocompativility and controlled release behavior of a model drug from nanoporous silica microparticles (NPSM). When Mouse osteoblastic cells (MC3T3-E1) were exposed to NPMSs, they indicated excellent cell viability. From NPSM contained in dental glass ionomer cement (NPMS-GIC), they can release cationic model drug molecules gradually in water for 2 weeks when they were contained in GIC. In contrast, GIC without NPSM specimens released the molecule only a couple of days. In the case of inionic molecules, their release were alos determined only a couple of days. These results suggest that NPSM can be used as a sustainable drug-release system in dental and medical fields
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