Control releasing 5-aminosalicylic acid using pH-sensitive hydrogel with novel albumin cross-linker

Abstract

Intelligent drug delivery systems are growing and changing too fast, these systems usually show a proper response at the proper time to one or several environmental factors. In the current research a biodegradable drug delivery system (pectin-g-PMA-co-PAAm) was designed and synthesized to release 5 aminosalicylic acid (5-ASA). The synthesized hydrogel is based on natural pectin and is in the form of simultaneous graft copolymerization of synthesized acryl-acid and acryl-amid. Using vinylized bovine serum albumin (VBSA) as cross linker agent is amongst important characteristics of this hydrogel. VBSA was synthesized through BSA modification with methylene-bis-acrylamide (MBA). In addition to having high water absorption, this hydrogel is pH-sensitive. In vitro tests under acid and base conditions of stomach show that this hydrogel is an appropriate option to release drugs through mouth. SEM analysis images show that synthesized hydrogel has a porous surface composed of nano and micro cavities.