Abstract
The capability of mixed polymer brush systems to modify and switch physico-chemical properties of biointerfaces is demonstrated in this paper. Mixed brushes were composed of the temperature sensitive polymer poly(N-isopropyl acrylamide) (PNIPAAM) and two polyelectrolytes, poly(2-vinylpyridine) (P2VP) and poly(acrylic acid) (PAA). Using these polymers binary brushes were prepared, the first one consisting of PNIPAAM – P2VP representing a system sensitive for temperature and pH changes, and the second one consisting of two polyelectrolytes (P2VP-PAA) showing sensitivity to pH changes of the surrounding fluid. Selected aspects concerning the environmental sensitivity as well as the protein adsorption affinity of these brushes are discussed. The stimuli-response towards temperature (PNIPAAm-P2VP) and pH (P2VP-PAA) of these binary polymer brushes was utilized to switch the adsorbed amount of protein and finally to regulate cell adhesion at brush coated surfaces.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.