Abstract
SummaryControl of ovulation time was attempted in clomiphene-induced cycles. Sixteen patients with anovulation were treated with clomiphene, 50–150 mg a day, and given a small dose of oestrogen in an attempt to regulate the time of ovulation. The clomiphene was started on day 5 of progestagen-induced uterine bleeding and continued for 5 days. Conjugated equine oestrogen, 0.1 mg, was given daily from days 9 to 14. Ovulation on days 14 to 16 of progestagen-induced bleeding was achieved. Treatment with clomiphene and oestrogen resulted in pregnancy in 6 of the 16 patients, who had all failed to conceive when treated with clomiphene alone. The results suggest that combination with oestrogen treatment is an effective means of controlling clomiphene ovulation time.
Published Version
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