Abstract
Mitochondrial Ca2+ uptake mediated by the Ca2+ uniporter plays important effector and modulator roles in cellular Ca2+ signaling. The activation of the uniporter generally requires cytosolic [Ca2+] ([Ca2+]c) >1μM; however, in certain cell types i is activated at much lower [Ca2+]c. We have recently identified the EF-hand protein MICU1 being responsible for both the relatively high threshold and positive cooperativity of the uniporter's activation by [Ca2+]c.
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