Abstract
The molecular devices that adjust the velocity of energy-producing metabolic pathways to the energetic requirements of cells, similar to those regulating blood flow to match metabolic needs, have proved to be rather elusive. Thus, although there is abundant information on various pathways of metabolism, as well as on the enzymatic mechanisms controlling their rates, relatively little is known about overall regulation of metabolism, i.e. about the mechanisms that couple function, metabolism and blood flow in the intact tissue (see e.g. 1,2).
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