Abstract
Abstract In the present paper some control mechanisms of RNA and haemoglobin synthesis during the differentiation of erythroid cells are described. The experiments were performed with yolk sac derived erythroid cells from mouse embryos which form a pure population of cells differentiating in vivo in a homogeneous fashion. The following results are presented: a) The synthetic capacity for the embryonic haemoglobins EI, EII and EIII change as yolk sac erythroid cells differentiate. The synthesis of these haemoglobins is Actinomycin-insensitive and it does not depend on continued messenger-RNA synthesis. The ribosome content is studied in relation with haemoglobin synthesis thus giving evidence for the hypothesis of a mechanism controlling protein synthesis at the level of translation. b) Irradiated erythroid cells are no longer capable of cell division, but synthesize haemoglobin at a rate double in comparison with control cells. The content of polyribosomes in irradiated cells is similar to the one of cont...
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