Abstract
In this chapter, the control of hemoglobin synthesis is considered with respect to a few selected topics including sites of erythropoiesis during fetal development, changes in cell structure during differentiation of erythroid cells, conversion from synthesis of fetal to adult types of hemoglobins, and rates of synthesis of different hemoglobins during erythroid cell differentiation. In considering these problems related to hemoglobin synthesis during erythroid cell differentiation, the chapter focuses on studies of the erythroid cell system in mouse and in man. The shift from embryonic to adult type of hemoglobin, at least in the fetal mouse, is associated with the substitution of one erythroid cell population for another. The changes in types of hemoglobin formed during development of mice, as well as of man, appear to involve substitutions with respect to the type of β chain formed, with the type of a chain being synthesized remaining unchanged. Hemoglobin synthesis in erythroid cells appears to proceed on relatively stable templates.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
