Abstract

Since the pioneering work of Moore and Price (1932), it has been well documented that the ovary and anterior pituitary gland (AP) exist in a dynamic equilibrium. Simply stated, the AP secretes the gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH). These glycoproteins bind to the ovary at specific receptor sites and stimulate the synthesis and secretion of ovarian steroids. These steroids travel from the ovary, through the peripheral circulation, to the AP and the hypothalamus (the area of the brain that regulates the secretions of the AP) to stimulate or inhibit further gonadotropin secretion.

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