Abstract
In this study, we demonstrate the fabrication of Y-doped bioactive glass (BG), which is proposed as a potential material for selective internal radiotherapy applications. Owing to its superior bioactivity and biodegradability, it overcomes the problem of yttrium aluminosilicate spheres that remain in the host body for a long duration after treatment. The preparation of Y-doped BG powders were carried out using a spray pyrolysis method. By using two different yttrium sources, we examine the change of the local distribution of yttrium concentration. In addition, characterizations of phase information, particle morphologies, surface areas, and bioactivity were also performed. The results show that both Y-doped BG powders are bioactive and the local Y distribution can be controlled.
Highlights
Bioactive glass (BG) has been studied extensively since its first report by Hench et al [1]
Pure bioactive glass (BG) powder was synthesized using spray pyrolysis based on the composition of
The results indicate that both pure and Y-doped BG powders
Summary
Bioactive glass (BG) has been studied extensively since its first report by Hench et al [1]. It was the first synthetic material to show a bone-bonding ability and has been successfully applied to various applications such as drug carriers, tooth fillers, and bone scaffolds [2,3,4]. Among these three applications, the development of drug carriers was the latest and is not mature yet. In recent years, one popular application of drug carrier BG is selective internal radiation therapy (SIRT), which has been used for tumor tissue treatments [5,6,7].
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