Abstract
Antibiotic contamination of water and food is a particularly important environmental worldwide problem. Antibiotics are found in water, soil, and food, which negatively affects both the environment and the health of the entire world’s population. Therefore, it is important to control the content of antimicrobials. To solve this problem, scientists are developing new and improving existing methods for these preparation determination. The paper considers the possibility of applying the technique of high-performance liquid chromatography with mass spectrometric detection for the determination of nitroimidazole group antibiotics in meat raw materials. The method was evaluated in terms of the main characteristics taken into account during validation: accuracy, reproducibility, linearity, and specificity. Studies conducted on pork muscle tissue samples showed the absence of antibiotics of this group in all samples, which meets the requirements of regulatory documents.
Highlights
Antibiotics are firmly established in our lives primarily as drugs for therapeutic purposes for animals and humans
The residual content of nitroimidazoles was determined by high-performance liquid chromatography with mass spectrometric detection (HPLC-MS/MS)
The method of high-performance liquid chromatography is a sensitive method for determining residual antibiotics in the form and food products [8,9,10]
Summary
Antibiotics are firmly established in our lives primarily as drugs for therapeutic purposes for animals and humans. Since it is not easy to remove antibiotics by simple methods, these drugs enter the human body, forming resistant strains of microorganisms, hypersensitivity of the body, intestinal microbiota dysbiosis. This problem causes serious concerns around the world [1,2,3]. After the last use of the drug, animal slaughter is allowed no earlier than three days later, poultry - after 5 days. The use of food products containing a residual content of antimicrobial drugs, including nitroimidazole groups, in the diet can contribute to the emergence of addiction (resistance) to each group of drugs and the development of resistant forms of microorganisms. It is very important to control the contamination with antimicrobial drugs
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
