Abstract
Control of Actin Dynamics in Cell Motility: ROLE OF ADF/COFILIN
Highlights
A large number of cellular processes, including cytokinesis, endocytosis, chemotaxis, or neurite outgrowth, is mediated by polymerization of actin filaments
Barbed end growth of filaments initiated at the leading edge is fed by subunits provided by continuous depolymerization of filaments from their pointed ends at the rear of the lamellipodial extension, which is maintained at a constant width [6]
actin-depolymerizing factor (ADF)/cofilin appears diffusely distributed in the cytoplasm of quiescent cells, the activated protein translocates to regions of the cells where actin filaments are highly dynamic, like the leading edge of ruffled membranes, the cleavage furrow of dividing cells, or the neuronal growth cone [11, 24, 25]
Summary
A large number of cellular processes, including cytokinesis, endocytosis, chemotaxis, or neurite outgrowth, is mediated by polymerization of actin filaments. ADF/cofilin appears diffusely distributed in the cytoplasm of quiescent cells, the activated (dephosphorylated) protein translocates to regions of the cells where actin filaments are highly dynamic, like the leading edge of ruffled membranes, the cleavage furrow of dividing cells, or the neuronal growth cone [11, 24, 25]. 2) ADF-decorated filaments depolymerize 30-fold more rapidly from their pointed ends than bare filaments, leading to steadystate accumulation of ADF-ADP-G-actin, ATP-G-actin, and a higher rate of barbed end assembly.
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