Actin cytoskeleton in ischemic acute renal failure

Abstract

A 36-year-old African American man was evaluated in the emergency room at Wishard Memorial Hospital following a motor vehicle accident. The patient’s car was hit from behind, and as he fled the scene of the accident, he fell and rolled down a hill. He was subsequently detained by police and brought to the hospital for evaluation of diffuse trauma and myalgias. In the emergency room, he was awake and alert but tachycardic, with a heart rate of 136 beats/min, a respiratory rate of 20 breaths/min, and a blood pressure of 104/57 mm Hg. The trauma team’s evaluation disclosed no significant injuries. However, he was admitted for evaluation and hydration, and because of an elevated serum creatinine level. His medical history was remarkable for a solitary right kidney, excessive alcohol intake, and use of crack cocaine, but he denied illicit intravenous drug use. He was taking no prescribed medications and had no history of diabetes, hypertension, or past surgeries. He had no known allergies. The baseline serum creatinine had been 1.2 mg/dL