Control Effect of Palmitoyl Teterapeptide-7 Gel to Inflammatory Responses Elicited by PM10

Abstract

Purpose: As a cosmetic approach to prevent pollution-induced skin damage, the topical application of skincare products, infused with functional ingredients, can offer an optimal solution to skin problems. The study aims to assess the anti-inflammatory effect of PT-7 gel. Methods: This study prepared antipollution cosmetics using palmitoyl tetrapeptide-7 (PT-7; 3% PT-7 gel, 5% PT-7 gel) and performed safety testing. For the safety assessment, the human repeat insult patch test (HRIPT) was performed to detect erythema occurrence on the patch area, following the ICDRG criteria. The panels comprised of 30 adults, aged 20–50 years. Furthermore, this study also analyzed particulate matter (PM) 10-induced inflammation on the skin of a hairless mouse by immunohistochemistry and Western blot. Results: The cosmetic safety testing results showed no skin reactions to antipollution gels containing PT- 7. Immunohistochemistry and the Western blot analysis demonstrated reduced levels of IL-1β and IL-6 expression levels in the 3% PT-7 and 5% PT-7 application groups after PM10 treatment. In particular, after PM10 treatment, the IL-1β and IL-6 expression levels were statistically significantly decreased in the group treated with 5% PT-7. Conclusions: Collectedly, this study provided evidence of the PT-7 gel’s safety and found that PT-7 gel reduced the IL-1β and IL-6 expression levels caused by PM10 exposure. In view of these results, it supports that PT-7 is a promising antipollution cosmetic ingredient with great commercial potential.