Abstract
The association of IsK with cell volume regulatory mechanisms has previously been proposed in gerbil vestibular dark cells (Ref. 40; also Wangemann, P., and Shiga, N. (1994) Am. J. Physiol. 266, C1046–C1060), although a more recent study carried out in murine vestibular dark cells (11) disagrees with this view, probably reflecting the involvement of different regulatory mechanisms between the two species. A different approach to the study of modulation of IsK by cell swelling, using electrophysiological techniques, has shown the increase in IsK current following hypotonic shock in oocytes expressing IsK (41).
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