Abstract
Chronic alcohol-feeding to mice results in an increased utilization of DPNH by hepatic mitochondria, in the presence and absence of “malate-aspartate shuttle” components. The utilization of alcohol and α-glycerophosphate by these mitochondria is also increased. Succinic dehydrogenase activity assayed with phenazine methosulphate as an index of mitochondrial permeability showed higher activity in mitochondria from chronic alcohol-treated mice compared to pair-fed controls. Alcohol-withdrawal from chronically-treated animals showed a lack of correlation between blood alcohol clearance, and hepatic microsomal alcohol-oxidizing activity on one hand, and between blood alcohol clearance and alcohol dehydrogenase activity on the other.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Biochemical and Biophysical Research Communications
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
