Abstract
Phloretin, a molecule which is known to decrease the dipole potential of lipid membranes, has a little effect on the CO frequencies of dimyristoylphosphatidylcholine bilayers (DMPC) in comparison to that observed on the phosphates. In the first case, the frequency is displaced very slightly to higher values, while a pronounced downward shift is observed on the asymmetric vibration frequencies of the phosphates. The effect of phloretin on the phosphate groups is correlated with a decrease in the monolayer potential of DMPC in the gel and in the liquid crystalline state. From the comparison with monolayers spread on water and on 0.15 M trehalose, it is concluded that the PO bonds of the phosphates can contribute to the dipole potential of the membrane in addition to the contribution given by the orientation of the -P−N+ dipole.
Published Version
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