Abstract
In a series of 49 aryl sulphoxides, the partition coefficients (log P) estimated by high-performance liquid chromatography were compared with log P values calcualted according to the hydrophobic fragmental method of Rekker and a modification of the method of Moreau. Moderate correlations were found. The introduction of Hammett sigma values as a measure of electronic effects proved to be good correction factors for the calculated log P values. In the presence of strong electron-withdrawing substituents, the sulphoxide moiety is far less hydrophobic than in the absence of such groups.
Published Version
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