Abstract
BackgroundTo systematically evaluate the visual performance of aspheric AcrySof IQ and spherical AcrySof Natural intraocular lens (IOL) after cataract surgery.Methodology/Principal FindingsPotential randomized controlled trials (RCTs) that involved implanting AcrySof IQ and AcrySof Natural were searched from PubMed, Web of science, EMBASE, Chinese Science and Technology Periodicals Databases and Cochrane Central Register of Controlled Trials. The methodological quality of the studies was assessed by the Jadad method. Standardized mean differences (SMDs) with 95% confidence intervals (CIs) of best-corrected visual acuity (BCVA), contrast sensitivity and spherical aberration were pooled using a random-effects model. Seven studies were identified and analyzed to compare AcrySof IQ (236 eyes) with AcrySof Natural (232 eyes) after phacoemulsification. There was no significant difference in postoperative BCVA between AcrySof IQ and AcrySof Natural (p =0.137) after a follow up of 3 months. For contrast sensitivity, these differences reached statistical significance under photopic conditions at two spatial frequencies (3 cycles per degree (cpd), 6 cpd, 12 cpd, and 18 cpd; p =0.022, p =0.017, p = 0.065, and p=0.191, respectively) and under mesopic conditions at three spatial frequencies (3 cpd, 6 cpd, 12 cpd, and 18 cpd; p =0.007, p =0.033, p =0.030, and p =0.080, respectively). Eyes with AcrySof IQ also had statistically significant less spherical aberration than eyes with AcrySof Natural (p<0.001). Sensitivity analysis showed that the results were relatively stable and reliable.Conclusions/SignificanceThe overall findings indicate that AcrySof IQ with a modified aspheric surface induced significantly less spherical aberration than AcrySof Natural. Contrast sensitivity in eyes with AcrySof IQ is better than that in eyes with AcrySof Natural, especially under mesopic conditions.
Highlights
Cataract is the leading reason of blindness in the world, and usually has to be treated surgically [1].At present, the main surgical procedures are phacoemulsification and intraocular lens (IOL) implantation [2].With the improvement of life quality, cataract surgery has developed from a procedure for the safe removal of the cataract to one aimed at refining to achieve the best possible postoperative refractive result [3]
Meta-Analysis Results Differences in mean changes in best-corrected visual acuity (BCVA) after implantation, along with Standardized mean differences (SMDs) and 95% confidence intervals (CIs), are presented in Figure 1.The analysis results of BCVA of each study were presented in a forest plot
We found no individual study could alter the pooled results of BCVA (SMD = 0.399, 95% CI -0.09 to 0.73, p =0.137),contrast sensitivity under photopic conditions (SMD= 0.389, 95%CI 0.19 to 0.53, p
Summary
Cataract is the leading reason of blindness in the world, and usually has to be treated surgically [1].At present, the main surgical procedures are phacoemulsification and intraocular lens (IOL) implantation [2].With the improvement of life quality, cataract surgery has developed from a procedure for the safe removal of the cataract to one aimed at refining to achieve the best possible postoperative refractive result [3]. Contrast sensitivity function, measured under varying conditions of luminance and glare, establishes the limits of visual perception across the spectrum of spatial frequencies [7,8]. It determines the relationship between the optical efficiency of the eye and minimal retinal threshold for pattern detection, which is not detected by the measurement of Snellen visual acuity [8]. Standardized mean differences (SMDs) with 95% confidence intervals (CIs) of best-corrected visual acuity (BCVA), contrast sensitivity and spherical aberration were pooled using a random-effects model. Contrast sensitivity in eyes with AcrySof IQ is better than that in eyes with AcrySof Natural, especially under mesopic conditions
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