Abstract
Treatment of menopausal symptoms with a combination of natural oestrogens (17β-ocstradiol and oestriol) and a gestagen (norethisterone acetate), given continuously without interruption, has been found to have a good effect on menopausal symptoms, at the same time as the endometrium is maintained or brought to an atrophic state. This method seems to be a new approach to oestrogenic replacement therapy, and in spite of the inconvenience of rather frequent - though as a rule very slight - bleeding during the first months of treatment, it should be of value. After 3–4 mth of treatment bleeding practically never occurs and the endometrium almost invariably becomes completely atrophic. It would seem that this might imply a lowered risk of development of endometrial cancer. A series of 265 patients treated in accordance with this principle for up to more than 4 yr is presented.
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